Cancer isn’t funny. It may, in fact, be the least funny topic one can broach. Yet somehow, behind-the-scenes guy and screenwriter Will Reiser has found a way to tell a story about cancer that produces more than a few laughs. It certainly helps that the story is Reiser’s own (with a few changes); the writer was diagnosed with a rare form of cancer at 24. Though we’re quick to outrage when someone mocks the sick or oppressed, we’re happy to join in when the sick and oppressed mock themselves. And nobody can deny that laughter is an ice pick for fear. Any way you look at it, Reiser and Director Jonathan Levine have broken a barrier once thought unbreakable and created 50/50, perhaps the world’s first successful cancer joke.